M4ndalore is a metrovirus which primarily affects the brain of an infected host. The virus usually presents itself by causing a steady decrease in sociability, over time driving the host to a complete contrarian lifestyle. The final stages of infection are characterized by the lightening of hair as the virus attacks hair follicles, turning them white.

The virus is believed to be work of a mad scientist, M4ndalore, from planet M4ndalore.

The only known cure to the M4ndalore virus is anime.